Home Neuronal Signaling Dopamine Receptor agonist SKF38393 HCl For research use only.

SKF38393 HCl

SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.

SKF38393 HCl Chemical Structure

SKF38393 HCl Chemical Structure

CAS No. 62717-42-4

Purity & Quality Control

Batch: S799301 DMSO]58 mg/mL]false]Ethanol]6 mg/mL]false]Water]5 mg/mL]false Purity: 99.57%
99.57

SKF38393 HCl Related Products

Signaling Pathway

Dopamine Receptor Signaling Pathways

Dopamine Receptor Signaling Pathway

Biological Activity

Description SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.
Targets
dopamine D1 receptor [1] D5 receptor [1]
In vitro
In vitro SKF38393 (50-100 μM) induces long-lasting synaptic potentiation in a protein synthesis-dependent manner. [1] In rat prefrontal cortical neurons in vitro, SKF 38393 mimicks the effects of DA on I(NaP), and modulates a persistent sodium current. [2] In the auditory cortex, SKF38393 affects long-term memory formation and consolidation by activating the downstream effectors adenylyl cyclase and phospholipase C-prominent proteomic alterations. [4]
In Vivo
In vivo SKF 38393(6 mg/kg, i.p.) prevents the scopolamine-induced impairment of performance of a T-maze working memory task. [3] In adult male NMRI mice, SKF38393 (1 μg/mouse) impaires context-dependent fear learning. [5]
Animal Research Animal Models Male Wistar rats
Dosages 6 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 291.77 Formula

C16H17NO2 . HCl
CAS No. 62717-42-4 SDF Download SKF38393 HCl SDF
Smiles C1CNCC(C2=CC(=C(C=C21)O)O)C3=CC=CC=C3.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 58 mg/mL ( (198.78 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 6 mg/mL

Water : 5 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

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